A BENEO-Orafti Newsletter - Spring 2008 - Nr. 18:
Prebiotics and healthy ageing

In the picture: Prebiotics and healthy ageing

Body weight evolution over time of the two feeding regimens is given in Figure 1 (males) and Figure 2 (females). The body weight of the males in the Synergy1 group was lower compared to the control males during the whole experiment and differences reached significance at 6 (P<0.01), 9, 12, 21 and
24 months of age (all P<0.05). The body weight of the females in the Synergy1 group was also lower compared to the control group and differences between groups were significant at 6 (P<0.05),
9 (P<0.01) and 12 months of age (P<0.05). No consistent changes in the level of food intake were observed throughout the study period. In the male rats, the level of fat mass in the Synergy1 group showed a tendency towards lower deposition compared to the controls. Also for the female rats, a similar trend towards a lower fat mass deposition in the Synergy1 group compared to the control group was observed.

In the male rats, cholesterol levels were similar between both groups at 12 months of age and levels were significantly lower in the Synergy1 group after 18 and 24 months of age (P<0.01 and P<0.05, respectively). Triglyceride levels in males were also lower in the Synergy1 group compared to the control group during the whole intervention and differences were significant at 18 and 24 months of age (P<0.05 and P<0.005, respectively). In the female rats, levels of tri-
glycerides were also significantly lower in the Synergy1 group compared to the control group at 18 months of age (P<0.05 for both). Fasting glycaemia levels did not differ between groups at any time point.

male rats

female rats

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