A BENEO-Orafti Newsletter - Spring 2008 - Nr. 18:
Prebiotics and healthy ageing

In the picture: Prebiotics and healthy ageing

In conclusion, life-long supplementation with Orafti®Synergy1 in rats delays the onset of age-related physiological and morphological changes (body weight, fat mass, blood levels of cholesterol and triglycerides) and prolongs life.
This is the first time that increased survival rates of both male and female rats are demonstrated after a life-long supplementation with a prebiotic ingredient. The mechanisms underlying this prolongation of life with Orafti®Synergy1 supplementation remain unclear. It can be hypothesised, however, that this effect is linked to the beneficial changes in biomarkers observed in the current study. Inulin-type fructans
stimulate health promoting bacteria in the large intestine, thereby improving digestive health which is vital to maintain overall health and well-being throughout life.

male rats

female rats

Mueller S, Saunier K, Hanisch Ch, Norin E, Alm L, Midtvedt T, Cresci A, Silvi S, Orpianesi C, Verdenelli MC, Clavel T, Koebnick C, Zunft H-J, Doré J,

Blaut M (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl. Environ. Microbiol. 72: 1027-1033.

Kleessen B, Sykura B, Zunft H-J, Blaut M (1997) Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in ederly constipated persons. Am. J. Clin. Nutr. 65: 1397-1402.

Mitsuoka T, Hayakawa K (1973) The fecal flora in man. I. Composition of the fecal flora of various age groups. Zentralbl. Bakteriol. 223: 333-342.

Rozan P, Nejdi A, Hidalgo S, Bisson J-F, Desor D, Messaoudi M (2008) Effects of life-long intervention with an oligofructose-enriched inulin in rats on general health and lifespan. Brit. J. Nutr. (in press).

Zunft H-J F, Hanisch C, Mueller S, Koebnick C, Blaut M, Doré J (2004) Synbiotic containing Bifidobacterium animalis and inulin increases stool frequency in elderly healthy people. Asia Pac. J. Clin. Nutr. 13: S112.

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